Comic Book Guy: [Glibly walking down sidewalk while reading comic book] But Aquaman, you cannot marry a woman without gills. You're from two different worlds! [the nuclear missile closes in on him] Comic Book Guy: Oohh, I've wasted my life... [mushroom cloud]
This quote occurs at 00:03:21-00:03:33 in the video.
Homer battles mutants after Springfield is annihilated by a neutron bomb; Bart has his DNA mixed with a fly; Marge is revealed to be a witch in colonial Springfield.
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